Fungal infections are increasingly becoming a global health problem that is associated with high morbidity and mortality rates as well as devastating socioeconomic consequences.
90% of systemic fungal infection-related deaths are caused by five species: Candida, Aspergillus, Cryptococcus, Pneumocystis, and Mucormycosis

• Candida species are most common in hospital-acquired infections
  
  
• Aspergillus species are predominant in immunocompromised patients, i.e. cancer and HIV patients
  
  
• Cryptococcus and Pneumocystis also contribute to the significant morbidity and mortality associated with invasive fungal infections
  
  
• Mucormycosis has a low incidence of life-threatening infections compared to the other species, but is associated with high mortality rates
  
  

The extensive use over the last decades of safer but fungistatic rather than fungicidal agents, particularly of the azole class, has led to the emergence of multidrug resistant (MDR) fungal pathogens. This situation is now recognized by the WHO as a global health threat